Raman Spectral Analysis of Sub-Surface Tissues and Fluids

This invention enables non-invasive, in-vivo examination of sub-surface tissues using Raman spectroscopy.




Raman spectroscopy is a technique used to determine molecular characteristics of materials through detecting Raman features of scattered light. STFC has invented a non-invasive method of examining bone quality and composition of other biological tissues using Raman spectroscopy. In particular, this invention processes scattering from surface and sub-surface tissue layers through a form of spatial gating. This method is called Spatially Offset Raman Spectroscopy (SORS).



  • This is a non-invasive method of biological tissues which can be used for in vivo examinations of patients and living subjects
  • Incident probe beam from a laser is transmitted by optical fibres. A ring of optical fibres surrounding the transmission fibres collect scattered light which can be detected by CCD camera.
  • Uses Spatially Offset Raman Spectroscopy to determine biomedical characteristics of tissues at varying depths from the surface.



  • Medical diagnosis e.g. degenerative skeletal diseases such as osteoporosis.
  • Longitudinal monitoring of musculoskeletal disease.
  • Non-invasive detection of blood characteristics through skin.



Patent Information:
Country Serial No.
India 5070/DELNP/2007
China 200580047024.1
Germany 5808577
France 5808577
United Kingdom 5808577
United States 11/792701
Patent Cooperation Treaty PCT/GB2005/004529
For Information, Contact:
Elizabeth Bain
IP Manager
STFC Innovations
+44 (0) 1925 60 3680
06.a. Medicine, Human Health
06.b. Biology/Biotechnology